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5. HEADACHE ATTRIBUTED TO HEAD AND/OR NECK TRAUMA 6. HEADACHE ATTRIBUTED TO CRANIAL OR CERVICAL VASCULAR DISORDER 6.1. Headache attributed to ischaemic stroke or transient ischaemic attack6.2. Headache attributed to non-traumatic intracranial haemorrhage [I62] 6.3. Headache attributed to unruptured vascular malformation [Q28] 6.4. Headache attributed to arteritis [M31]6.5. Carotid or vertebral artery pain [I63.0, I63.2, I65.0, I65.2 or I67.0]6.6. Headache attributed to cerebral venous thrombosis (CVT) [I63.6] 6.7. Headache attributed to other intracranial vascular disorder6.7.1. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) [I67.8] 6.7.2. Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like episodes (MELAS) [G31.81] 6.7.3. Headache attributed to benign (or reversible) angiopathy of the central nervous system [I99] 6.7.4. Headache attributed to pituitary apoplexy [E23.6] Bibliography7. HEADACHE ATTRIBUTED TO NON-VASCULAR INTRACRANIAL DISORDER 8. HEADACHE ATTRIBUTED TO A SUBSTANCE OR ITS WITHDRAWAL 9. HEADACHE ATTRIBUTED TO INFECTION 10. HEADACHE ATTRIBUTED TO DISORDER OF HOMOEOSTASIS 11. HEADACHE OR FACIAL PAIN ATTRIBUTED TO DISORDER OF CRANIUM, NECK, EYES, EARS, NOSE, SINUSES, TEETH, MOUTH OR OTHER FACIAL OR CRANIAL STRUCTURES 12. HEADACHE ATTRIBUTED TO PSYCHIATRIC DISORDER 

IHS	Diagnosis	ICD-10
6.7.2	Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like episodes (MELAS) [G31.81]	G44.81

Diagnostic criteria:

Attacks of migraine with or without aura
Stroke-like episodes and seizures
Genetic abnormality (3243 point mitochondrial DNA mutation in the tRNA Leu gene or other DNA MELAS point mutation)

Comment:

Migraine attacks are frequent in MELAS and this has led to the hypothesis that mitochondrial mutations could play a role in migraine with aura but the 3243 mutation was not detected in two groups of subjects with migraine with aura. Other yet-undetected mutations may play a role in both migraine and ischaemic stroke since migraine attacks, mostly with aura, also occur in other mitochondrial disorders.

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IHS vs. ICD-10

To facilitate headache diagnosis in daily practice, the classification provides the corresponding WHO ICD-10NA codes for each IHS code.

IHS Subcommittee

The Classification Subcommittee prepares and revises the International Classification of Headache Disorders.

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Cephalalgia

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