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IHS Diagnosis ICD-10
8.1.9.2 Delayed CGRP-induced headache [X44] G44.40  

Diagnostic criteria:

  1. Headache, in a person who suffers from primary headache, with the characteristics of that primary headache type1 and fulfilling criteria C and D
  2. Absorption of CGRP
  3. Headache develops after CGRP is cleared from the blood2
  4. Headache resolves within 72 hours after infusion of CGRP

Notes:

  1. Normal subjects rarely develop delayed CGRP-induced headache whilst migraineurs develop an attack of migraine without aura, tension-type headache sufferers develop a tension-type headache and cluster headache sufferers develop a cluster headache attack.
  2. Migraine and tension-type headache develop typically after 5-6 hours, cluster headache typically after 1-2 hours.

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