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The International Headache Society (IHS) is the world's membership organisation for all whose professional commitment, whatever their discipline, is to helping people whose lives are affected by headache disorders.Visit the IHS website

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IHS Diagnosis ICD-10
8.3 Headache as an adverse event attributed to chronic medication [code to specify substance] G44.4  

Diagnostic criteria:

  1. Headache present on >15 days/month fulfilling criteria C and D
  2. Chronic medication1 for any therapeutic indication
  3. Headache develops during medication
  4. Headache resolves after discontinuation of medication2

Notes:

  1. The definition of dose and duration will vary with the medication.
  2. Time for resolution will vary with the medication but may be months.

Comment:

Headache can be due to a direct pharmacologic effect of medication, such as vasoconstriction producing malignant hypertension and headache, or to a secondary effect such as drug-induced intracranial hypertension. The latter is a recognised complication of long-term use of anabolic steroids, amiodarone, lithium carbonate, nalidixic acid, thyroid hormone replacement, tetracycline or minocycline.

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