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IHSDiagnosisICD-10
10.3.6Headache attributed to acute pressor response to an exogenous agent [code to specify aetiology] G44.813  
Coded elsewhere 8.1.6 Cocaine-induced headache .

Diagnostic criteria:

  1. Headache, no typical characteristics known, fulfilling criteria C and D
  2. An appropriate agent or toxin has been administered or ingested and an acute rise in blood pressure has occurred
  3. Headache develops in close temporal relation to the acute rise in blood pressure
  4. Headache resolves within 24 hours after normalisation of blood pressure
  5. No other mechanism for the headache is apparent

Comments:

Apart from cocaine, agents that can produce acute elevations of blood pressure include sympathomimetics and amphetamines, and monoamine oxidase inhibitors when interactions with tyramine-containing foods occur.

There is insufficient evidence to set criteria for how large an elevation in blood pressure is required to produce headache, and this may vary from person to person. Criterion D is arbitrary, but included to increase the specificity of the diagnostic criteria.

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